Mechanisms of Interferon Invasion by RNA Viruses
The filoviruses, Ebola virus (EBOV) and Marburg virus (MARV) cause frequently lethal viral hemorrhagic fever. These infections induce potent cytokine production, yet these hosts responses fail to prevent systemic virus replication. Filoviruses have been found to encode proteins that block host interferon production and signalling. Our interest is to determine how RNA viruses such as MARV and EBOV differ in this mechanism to persist.
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